Zhejiang Tasln Biopharma Co.,Ltd

Retatrutide API

CAS No.: 2381089-83-2
Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight: ~4,731 g/mol
Purity: ≥99% by HPLC
Grade: Pharmaceutical Grade / Research Grade
Storage: 2-8°C, protected from light, sealed
Shelf Life: 24 months
GMP Compliance: cGMP
DMF Status: In preparation

Product Description

Retatrutide (LY3437943) is a first-in-class triple agonist targeting GIP, GLP-1, and glucagon (GCG) receptors. It is a 39-amino acid synthetic peptide engineered from a GIP peptide backbone, featuring non-coded amino acid residues for enhanced stability and activity. The half-life is approximately 6 days, supporting once-weekly administration.

Key Features

• Triple GIP/GLP-1/GCG receptor agonist

• Once-weekly dosing

• Phase 2 weight loss: up to 24.2% at 48 weeks

• Phase 3 program ongoing (TRIUMPH)

• cGMP manufacturing

• DMF in preparation

Mechanism of Action

Receptor	Primary Effect
GIP	Enhances insulin sensitivity, regulates lipid metabolism
GLP-1	Promotes insulin secretion, suppresses appetite
GCG	Increases energy expenditure, promotes fat breakdown

Clinical Data

Dose	Weight Loss (48 weeks)
4 mg	17.1%
8 mg	22.8%
12 mg	24.2%
Placebo	2.1%

Applications

• Obesity and overweight research

• Type 2 diabetes studies

• Metabolic dysfunction-associated steatotic liver disease (MASLD) research

• Preclinical and clinical trial supply

Why Choose Us

• 20 years peptide experience

• cGMP certified

• ≥99% high purity

• 24-month shelf life at 2-8°C

• DMF filing support

• Reliable global supply

Packaging & Storage

Parameter	Condition
Storage	2-8°C, protected from light, sealed
Shelf Life	24 months
Shipping	Temperature-controlled (2-8°C)

Documentation

COA, stability data, GMP statement, DMF (in preparation)

Contact Us

For pricing, DMF status, or samples, please contact our sales team.